Ablukast
Ablukast is a leuktriene receptor antagonist that acts as an anti-asthmatic.
For research use only. We do not sell to patients.
Chemical Information
| Name | Ablukast |
|---|---|
| Iupac Chemical Name | 2H-1-Benzopyran-2-carboxylic acid, 6-acetyl-7-((5-(4-acetyl-3-hydroxy-2-propylphenoxy)pentyl)oxy)-3,4-dihydro-, (+-)- |
| Synonyms | Ablukast; Ro 23-3544; Ro-23-3544; Ro23-3544; Ro 233544; Ro-233544; Ro233544; Ro 23-3544/000; |
| Molecular Formula | C28H34O8 |
| Molecular Weight | 498.56 |
| Smile | O=C(C1CCC2=CC(C(C)=O)=C(OCCCCCOC3=CC=C(C(C)=O)C(O)=C3CCC)C=C2O1)O |
| InChiKey | FGGYJWZYDAROFF-UHFFFAOYSA-N |
| InChi | InChI=1S/C28H34O8/c1-4-8-21-23(12-10-20(17(2)29)27(21)31)34-13-6-5-7-14-35-26-16-25-19(15-22(26)18(3)30)9-11-24(36-25)28(32)33/h10,12,15-16,24,31H,4-9,11,13-14H2,1-3H3,(H,32,33) |
| CAS Number | 96566-25-5 (free acid) |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
| Targets | |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Rosenbach T, Csatò M, Czarnetzki BM. Studies on the role of leukotrienes in murine allergic and irritant contact dermatitis. Br J Dermatol. 1988 Jan;118(1):1-6. PubMed PMID: 2829957.
2: Sun J, Herman CA. Cardiovascular effects of N-methyl leukotriene C4, a nonmetabolizable leukotriene C4 analogue, and the antagonism of leukotriene-induced hypotension by Ro 23-3544, in the American bullfrog, Rana catesbeiana. Can J Physiol Pharmacol. 1995 Mar;73(3):383-9. PubMed PMID: 7648518.
3: Kumar S, Malick AW, Meltzer NM, Mouskountakis JD, Behl CR. Studies of in vitro skin permeation and retention of a leukotriene antagonist from topical vehicles with a hairless guinea pig model. J Pharm Sci. 1992 Jul;81(7):631-4. PubMed PMID: 1403694.
4: Meigel W. Allergic contact dermatitis--description of a test model for topical anti-inflammatories with particular reference to the leukotriene-C4 antagonist Ro-23-3544. Arch Dermatol Res. 1991;283(4):278-9. PubMed PMID: 1929548.
5: O'Donnell M, Welton AF, Crowley H, Brown D, Garippa R, Cohen N, Weber G, Banner B, Lopresti RJ. Pharmacological profile of Ro 23-3544, a new aerosol active leukotriene receptor antagonist. Adv Prostaglandin Thromboxane Leukot Res. 1987;17A:512-8. PubMed PMID: 2821764.
6: Binder D, Koch A, Rovenszky F, Stroissnig H. [Thiophene as a structural element of physiologically active substances. 20. Thiophene analogs of the leukotriene D4 antagonist Ro 23-3544]. Arch Pharm (Weinheim). 1992 Dec;325(12):797-801. German. PubMed PMID: 1489255.
Chemical Structure
